VEGFA and Familial prostate cancer: ZA inhibits the differentiation, migration and secretion of proangiogenic factors of mesenchymal stromal cells to suppress the growth, migration and angiogenesis of prostate cancer cells [93], including vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2), which are related to angiogenesis, immunosuppression and migration of cancer cells [94, 95].