It is reported that ZA inhibits Ras, blocks the Ras-dependent Erk 1/2 and Akt pathways, and then reduces the phosphorylation of both Bcl-2 and Bad, activates the caspase-dependent apoptosis pathway to kill cancer cells [76, 78, 79, 91] (Fig. 3). Here, AKT1 is linked to cancer.