In the present work, we planned to explore the potential effects of Hdac3 regulating miR-17 in the miR-17-92 cluster on the abnormal angiogenesis and alveolarization of BPD via EZH1-p65-Pgf axis, which may serve as a potential target to treat BPD. The gene discussed is HDAC3; the disease is bronchopulmonary dysplasia.