Furthermore, immunohistochemistry identified that the expression of EZH1, p65, and Pgf in lung tissues of hyperoxia + Hdac3−/−-treated mice was lower than that in BPD mice, whereas the expression of EZH1, p65, and Pgf in lung tissues of hyperoxia + Hdac3 −/− + miR-17-antagomir-treated mice was similar to the hyperoxia-induced BPD mice (Fig. 6f, Additional file 1: Fig. S1). This evidence concerns the gene RELA and bronchopulmonary dysplasia.