Our findings regarding the cases of male nondiabetic obese mice when compared with male nondiabetic normal mice indicate that obesity in the male population heavily affects genes related to the skeletal and cardiac tissues, which agrees with previous studies connecting obesity with impaired muscular structure and function, as well as abnormal regulation of insulin secretion and glucose homeostasis [46, 63, 64]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.