LEP and obesity due to melanocortin 4 receptor deficiency: Processes that were highly enriched in DE genes in female mice include digestion (GO:0007586), regulation of insulin secretion (GO:0050796), response to lipid (GO:0033993), fatty acid biosynthetic process (GO:0006633), increased energy expenditure (MP:0004889), decreased susceptibility to diet-induced obesity (MP:0005659), abnormal glucose tolerance (MP:0005291) and decreased circulating leptin level (MP:0005668).