HIF1A and cancer: In 1992, the hypoxia-inducible factor-1α (HIF1α) was found in Hep3B cells as a factor inducing erythropoietin under hypoxic conditions.8 After this finding, it was discovered that HIF1α also regulates a variety of biological responses (e.g., metabolic reprogramming,9 suppression of reactive oxygen species [ROS] production,10 angiogenesis,11 epithelial-mesenchymal transition,12 and cancer metastasis13).