Therefore, the differences in the sensitivity of glutamatergic transmission to activated hemichannels before (four weeks of age) and after (eight weeks of age) ADSHE seizure onset suggest that the activation of upregulated Cx43 in the OFC of S286L-TG likely contributes to the development of ictogenesis through the hyperactivation of tripartite synaptic transmission. The gene discussed is GJA1; the disease is Seizure.