Patients with severe SARS-CoV-2 show high levels of IL-2, IL-7, IL-10, granulocyte-colony stimulating factor [G-CSF], CXCL10, MCP-1, macrophage inflammatory protein 1-α, and TNF-α [6,63], which could enhance endothelial dysfunction and acute thrombosis, as shown in a case series of patients with severe SARS-CoV-2 and venous thrombosis or arteriosclerosis obliterans of lower extremities [64]. This evidence concerns the gene CSF3 and arteriosclerosis obliterans.