METTL3 and cardiac hypertrophy: Dorn et al., using a METTL3-overexpressing mice model, documented dose-dependent cardiac hypertrophy, while knockdown of METTL3 on neonatal rat cardiomyocytes (NRCM) blocked the hypertrophy after hypertrophic stimuli and METTL3 knock out mice showed sign of heart failure [49].