In particular, tumor-related genes, such as Wolf–Hirschhorn syndrome candidate 1 (WHSC1; also known as multiple myeloma SET domain (MMSET) or nuclear receptor binding SET domain protein 2 (NSD2)), were revealed to be affected by DNA methylation specifically in NASH-N and NASH-T liver tissues, which were not observed in viral-N and viral-T liver samples. This evidence concerns the gene NSD2 and metabolic dysfunction-associated steatohepatitis.