CASP1 and metabolic dysfunction-associated steatotic liver disease: Murphy et al. [121] found that tissue repair genes, such as fibroblast growth factor receptor 2 (FGFR2) and caspase 1 (CASP1), were hypomethylated and overexpressed, whereas a gene in one-carbon metabolism, methionine adenosyl methyltransferase 1A (MAT1A), which generates SAM, was hypermethylated and underexpressed in liver biopsies from patients with advanced NAFLD.