GNMT and hepatocellular carcinoma: Additionally, it was recently reported by Borowa-Mazgaj et al. [109] that gradual DNA hypermethylation at the promoter region in the glycine N-methyltransferase (Gnmt) gene decreased its gene expression in the livers of three different mouse models of NAFLD and NAFLD-derived hepatocellular carcinoma (HCC): a diet-induced animal model of NAFLD (DIAMOND), a Stelic animal model of nonalcoholic steatohepatitis-derived HCC (STAM), and a choline- and folate-deficient (CFD) diet model.