Moreover, Wegermann et al. [123], in their pilot study involving 86 patients with NAFLD (gene expression and clinical outcome data were available in only 55 patients), found that differential branched-chain amino-acid transaminase 1 (BCAT1) gene expression was correlated with changes in DNA methylation at three CpG loci of the BCAT1 gene in patients with NAFLD who experienced adverse clinical events such as cardiovascular outcomes and/or hepatic decompensation. Here, BCAT1 is linked to metabolic dysfunction-associated steatotic liver disease.