ACSL4 and metabolic dysfunction-associated steatotic liver disease: By comparing DNA methylation between the NAFLD and healthy control groups, they found that hypomethylated CpG sites of acyl-CoA synthetase long-chain family member 4 (ACSL4) and carnitine palmitoyltransferase 1C (CPT1C) among 863 differentially methylated CpG sites were significantly associated with an increased risk of NAFLD [138].