DNA methylation at particular CpG dinucleotides within the human PPARα and PPARγ gene promoters was upregulated (i.e., hypermethylation), whereas it was downregulated within the platelet-derived growth factor subunit A (PDGFA) gene promoter and transforming growth factor 1 (TGF1) exon 1 (i.e., hypomethylation) in severe NAFLD compared with mild NAFLD. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.