Among the four genes in which particular CpG methylation was repetitively found to be associated with the serum level of liver enzymes, including solute carrier family 7 member 11 (SLC7A11), SLC43A1, SLC1A5 and phosphoglycerate dehydrogenase (PHGDH), DNA methylation at the SLC7A11 intronic region (cg06690548) was significantly associated with a reduced risk of hepatic steatosis. The gene discussed is PHGDH; the disease is fatty liver disease.