MMP8 and periodontitis: ROC curves to discriminate healthy sites from mild to severe periodontitis sites showed high diagnostic accuracy for the MMP-8 crude model (AUC = 0.90, 95% CI 0.83–0.95), the MMP-8 adjusted model (AUC = 0.90, 95% CI 0.80–1.00), the TRAP-5 crude model (AUC = 0.85, 95% CI 0.77–0.91), and the TRAP-5 adjusted model (AUC = 0.88, 95% CI 0.76–0.99).