Knowing the MYC oncogene has been identified previously as a source for uncontrolled cell proliferation, we used The Cancer Genome Atlas (TCGA) breast invasive carcinoma cohort [15] as well as the Molecular Taxonomy of Breast Cancer International Cohort (METABRIC) [16] and GSE124647 [17] cohorts in order to study the expression of hallmark MYC targets v1 and MYC targets v2 gene sets [18] and their correlation with tumor aggressiveness as well as immune cell infiltration and survival in metastatic disease. This evidence concerns the gene MYC and metastatic neoplasm.