For a better understanding of the regulation of vitamin D metabolism and its relation to dyslipidemia, variants of several genes including VDR which encodes the vitamin D receptor, DHCR7 which encodes the enzyme 7-dehydrocholesterol reductase, CYP2R1 which encodes the hepatic enzyme 25- hydroxylase, CYP24A1 which encodes 24-hydroxylase, and GC which encodes DBP the transporting protein for vitamin D DBP should all be considered [53]. The gene discussed is VDR; the disease is metabolic syndrome.