COL5A1 and Ehlers-Danlos syndrome: Pathogenic variants causing forms of EDS in animals have been identified in known candidate genes for EDS (COL5A1, ADAMTS2, PLOD1) [5,7,8,10,13,15,18], or novel genes (EPYC, TNBX, PPIB) discovered in EDS-affected domestic animals [6,9,17].