In addition to cell death regulation, ASMase−/− mice are resistant to alcohol- or HFD-induced lipogenesis and macrosteatosis, and hence, the pharmacological inhibition of ASMase using amitriptyline or imipramine (tricyclic antidepressants) in wild-type mice (WT) blocked alcohol- and HFD-induced steatosis [30,51,60,84]. This evidence concerns the gene SMPD1 and steatosis.