SMPD3 and early-onset autosomal dominant Alzheimer disease: The treatment of wild-type mice and a 5XFAD Alzheimer’s disease mouse model with GW4869, an NSMase-2 inhibitor, resulted in lower exosome accumulation in the brains of 5XFAD mice, resulting in lower concentrations of Aβ1–42 and reducing Alzheimer ́s pathology [47].