TIA1 and infection: Since EBV-infected T/NK cells in CAEBV patients consistently express cytotoxic molecules, including T-cell restricted intracellular antigen 1 (TIA1), granzyme B, and perforin; infection via immunologic synapses formed between EBV-infected B cells and cytotoxic T or NK cells during target cell lysis has been proposed as a possible mechanism [28,77].