INS and obesity due to melanocortin 4 receptor deficiency: In fact, available evidence suggests that adequate consumption of fruits and vegetables is usually associated with lower EI and higher intakes of dietary fiber which, through colonic, intrinsic, and/or hormonal effects may be associated with increased satiety, increased fat oxidation, and increased insulin sensitivity, all of which may contribute to the prevention of obesity and metabolic abnormalities [95,127,128,129].