NEAT1 and neoplasm: However, it is important to note that this study did not distinguish between either isoform of NEAT1 leaving the possibility that the isoform NEAT1_1 is the target of HIF-2 induced gene expression of NEAT1. This means NEAT1_1 is the downstream factor in the hypoxic pathway and, therefore, it is NEAT1_1 that could be increasing the chemoresistance of a tumour, whilst the increased paraspeckle formation is just a side product [25].