The data showed that high expressions of EMT regulators Snail and vimentin, Bcl-2, and JUN were associated with a poor recurrence-free survival of breast cancer patients (Figure 6a–d), which may be explained by our findings that high expressions of these genes facilitated the survival of CTCs under blood shear stress that may enhance the metastatic risk and deteriorate patient survival. This evidence concerns the gene BCL2 and breast carcinoma.