The Ang/tyrosine kinase with immunoglobulin (Ig) and epidermal growth factor (EGF) homology domains 2 (Tie2) system thus exerts a critical role in neovascularization in conjunction with VEGF and might also present an interesting therapeutic target for HCC, as discussed further (Figure 1) [16,27]. Here, ANG is linked to hepatocellular carcinoma.