Whereas several groups showed that Ang-2 expression in patient HCC tissues is predictive for recurrence after surgical resection [22,63], Kuboki et al. were the first to demonstrate that high preoperative hepatic venous Ang-2 levels correlate with a shorter postoperative survival, strengthening the prognostic value of Ang-2 [58]. This evidence concerns the gene ANGPT2 and hepatocellular carcinoma.