Similarly, a significant downregulation of Ang-2 expression was also observed following interstitial chemotherapy using poly(lactic-co-glycolic acid) (PLGA) microspheres containing docetaxel in an HCC mouse model, suggesting that inhibition of Ang-2/Tie2-mediated angiogenesis may be an important mechanism involved in its antitumor activity [52]. This evidence concerns the gene ANGPT2 and hepatocellular carcinoma.