Combined with the pathway analysis, the heatmap revealed the differential methylation of different tumors, such as CYBA in prostate cancer and CSMD2 in lung cancer, which were previously reported to be involved in the progression of the respective cancers by being involved in the production of superoxide and/or hydrogen peroxides [83], which plays a role in the NRF2-KEAP1 pathway. The gene discussed is CSMD2; the disease is cancer.