SERPINE1 and neoplasm: Transforming growth factor-β1 (TGF-β1), lysyl oxidase (LOX), cystatin (CST3), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) proved to be involved in the turnover of ECM, wound healing, tumor invasion and metastasis (Figure 2) [37,38].