As observed with NK cell degranulation, NK cells from the MM group also produced a significantly less IFN-γ than those from HDs against P815-ULBP1+CD48 and 721.221 cells but not K562 cells (p < 0.01 against P815-ULBP1+CD48; p < 0.05 against 721.221) (Figure 1C,D). This evidence concerns the gene ULBP1 and Miyoshi myopathy.