Moreover, NK cells from the MM group exhibited a significant impairment in cytotoxic degranulation compared with those from HDs in response to P815-ULBP1+CD48 and 721.221 cells but not K562 cells (p < 0.01 against P815-ULBP1+CD48; p < 0.05 against 721.221) (Figure 1A,B). This evidence concerns the gene ULBP1 and Miyoshi myopathy.