CYP3A4 and obesity due to melanocortin 4 receptor deficiency: As also obesity, non-alcoholic fatty liver disease (NAFLD) and T2D negatively affect the activity a number of coenzymes of the P-450 system, including CYP3A4 [126,133,134], SJW treatment, primarily aimed at inhibiting the basic inflammatory state, would result in the added benefit of offsetting the repressed activity of P-450 system, hopefully achieving a balanced drug metabolizing function.