Actually, as mentioned above, expansion and activation of resident and recruited macrophages within the adipose tissue is considered a major event that occurs during obesity-induced inflammation, resulting in polarization of these macrophage in the M1 pro-inflammatory phenotype [178,179], and consequent increased production and release of TNF-α, IL-1β and IL-6, that largely contribute to the development of local and systemic insulin resistance [8,180,181]. The gene discussed is TNF; the disease is Insulin resistance.