However, also HYP has been recently shown to exert beneficial effects in animal models of obesity, NAFLD and T2D, mainly through unexpected modulation of metabolic pathway signaling, that merits mindful consideration, also because it can be complementary to the mechanisms of action of HPF, with the result of a reciprocal reinforcement when both present in the whole SJW extract. Here, PHEX is linked to obesity due to melanocortin 4 receptor deficiency.