FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: This is illustrated by the systemic autoimmune syndrome observed in Scurfy mice and Immunodysregulation Polyendocrinopathy Enteropathy X-linked (IPEX) patients who carry mutations in Foxp3 and after the ablation of Treg cells in young and adult mice [2,3,4,5].