These reports have highlighted a series of novel pathways, such as ubiquitin ligases and deubiquitinases, chromatin remodelers, and transcription factors; in particular, Loo et al. nicely demonstrated that ablation of the Bromodomain-containing protein 9 (Brd9) subunit of the non-canonical BRG1/BRM Associated Factors (BAF) complex, impaired Foxp3 expression and reduced Treg cell function, leading to enhanced tumor immunity and delayed growth of transplanted MC38 colon adenocarcinoma cells [129]. The gene discussed is FOXP3; the disease is neoplasm.