ACE2 and COVID-19: It is important to note that several potential therapeutic strategies targeting ACE2 have been already proposed to tackle COVID-19; however, mainly owing to the critical metabolic and hemodynamic roles of ACE2, including the regulation of glucose homeostasis [56,57,58,59] as well as the cleavage of Angiotensin I and Angiotensin II [60,61], these approaches could lead to major issues in the clinical scenario [57,62,63].