CD8A and breast cancer: Indeed, SERMs have been reported to be capable of promoting an immunosuppressive milieu in the context of BC TME [158,159,160] by (i) inducing CD4+ T-cell polarization towards a Th2 phenotype through the inhibition of DC differentiation, maturation and function, (ii) suppressing the cytotoxic immune activity through the inhibition of CD8+ T cells.