By contrast, GLO1 activity was increased in red blood cells of streptozotocin-induced diabetic C57BL/6 mice, compared to non-diabetic controls [185] and GLO1 activity was increased in the red blood cells of patients with type 1 diabetes and type 2 diabetes, compared to healthy control subjects [186]. The gene discussed is GLO1; the disease is type 2 diabetes mellitus.