Although initial potassium supplementation was performed in patients with severe COVID-19 manifestations [121], its impact on TMPRSS2 expression, ENaC activity, LDH levels, blood and urine osmolality, and the rate of viral replication has not been examined to validate the role of TMPRSS2/ENaC axes in the amplification of SARS-CoV-2 propagation and osmotic crisis. This evidence concerns the gene TMPRSS2 and COVID-19.