ACE2 and COVID-19: Although the extent of furin inhibition and facilitation of ACE2 shedding in a SARS-CoV-2 infected cells relative to other proposed mechanisms [187,188] needs to be examined further, a retrospective study demonstrated reduction of all-cause mortality from 9.4% to 5.2% in COVID-19 patients receiving cholesterol-lowering therapy with statins [189].