In a recent work, a significant influence of fats on site-specific DNA-methylation (DNA-me) relevant to T2D was found [68]; for instance, the associations between high levels of DNA-me in CpG (or CG island) site of a gene essential in cholesterol transport (ABCG1) correlated with fasting insulin and HOMA-IR in CD4+ T cells from non-diabetic individuals [69], suggesting that the derangements of the metabolic state that drive to T2D onset could be influenced by DNA-me on the obesogenic genes. Here, INS is linked to type 2 diabetes mellitus.