Chronic circadian misalignment is sufficient to disrupt the liver clock and circadian metabolism and to drive the development of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC) in mice, independently of dietary, exogenous, or genotoxic stress [78]. The gene discussed is CLOCK; the disease is metabolic dysfunction-associated steatohepatitis.