In male Tsumura Suzuki obese diabetes (TSOD) mice (a polygenic model that gradually develops obesity and type 2 diabetes), the mRNA expression of Pxr and Pgc-1α, but not of Car, was increased compared with control mice, resulting in increased CYP3A expression and activity. The gene discussed is NR1I2; the disease is obesity due to melanocortin 4 receptor deficiency.