Using atherosclerosis-prone Apoe−/− mice that were fed a Western diet to induce lesion formation, Karunakaran et al. showed that 6 weeks of treatment with Necrostatin-1 (Nec-1), an inhibitor of RIPK1, significantly reduced ascending and descending aorta atherosclerosis lesion burden [12]. The gene discussed is PCSK1; the disease is atherosclerosis.