Lou et al. found, using the Angiotensin II model of AAA, that mice deficient in STING (Stinggt/gt) were protected from aortic aneurysm, dissection, and rupture, and that levels of phosphorylated RIPK3 and MLKL in treated aortic tissues were significantly decreased in STING deficient mice. This evidence concerns the gene RIPK3 and triple-A syndrome.