In a cross-sectional study of 318 patients with stable coronary artery disease (CAD), unstable angina, and acute myocardial infarction, Hu et al. found that plasma levels of RIPK3 were significantly elevated in patients with CAD (406.87 (311.51, 516.59) pg/mL vs. 241.61 (175.83, 318.13) pg/mL) compared to healthy controls, and that plasma RIPK3 levels positively correlated with CAD severity (acute myocardial infarction > unstable angina > stable CAD). The gene discussed is RIPK3; the disease is acute myocardial infarction.