Given the importance of NETosis in venous thrombosis, and the finding that RIPK3 can contribute to NETosis in crystallopathies such as gout [85], Nakazawa et al. sought to investigate whether or not MLKL, the executor of necroptosis, drives NETosis in the context of venous thrombosis [86]. The gene discussed is RIPK3; the disease is Venous thrombosis.