The involvement of the genes RANBP1, MCM5, EIF3B, PSMA6, NPM1, and HSP90AB1 in the most significant regulatory pathways of the seventh and ninth cell subtypes was further confirmed in the nasopharyngeal carcinoma cell line (HONE-1), and cisplatin was used to screen for the expression of these genes in the drug-resistant HONE1-CIS6 cell line. Here, RANBP1 is linked to nasopharyngeal carcinoma.