MYOD1 and Cachexia: Furthermore, in gastrocnemius of mice exposed to either LC-induced cachexia or unloading compared to non-immobilized controls, total body and muscle weight, limb strength, CSA of fast-twitch muscle fibers, counts of quiescent satellite cells and myocytes, and myogenin levels significantly declined, whereas muscle damage including troponin I levels, proteolytic and autophagy (LC-cachexia) markers, activated satellite cell numbers, and MyoD levels were significantly greater.