GPC-3 was positively correlated to ALT (rs = 0.304, 95% CI 0.194–0.407, p < 0.001), AST (rs = 0.378, 95% CI 0.271–0.476, p < 0.001), HCC nodules number (rs = 0.206, 95% CI 0.032–0.369, p = 0.021) and the size of the major HCC nodule (rs = 0.289, 95% CI 0.119–0.443, p = 0.001) while negatively correlated to platelet count (rs = −0.161, 95% CI −0.269–−0.049, p = 0.005) and albumin (rs = −0.260, 95% CI −0.377–−0.135, p < 0.001). This evidence concerns the gene GPC3 and hepatocellular carcinoma.