AFP was positively correlated with ALT (rs = 0.316, 95% CI 0.207–0.417, p < 0.001), AST (rs = 0.396, 95% CI 0.291–0.491, p < 0.001), total bilirubin (rs = 0.156, 95% CI 0.035–0.272, p = 0.012) and the size of the major HCC nodule (rs = 0.289, 95% CI 0.119–0.443, p < 0.001) while negatively correlated to platelet count (rs = −0.238, 95% CI −0.341–−0.129, p < 0.001) and albumin (rs = −0.373, 95% CI −0.479–−0.256, p < 0.001). This evidence concerns the gene ALB and hepatocellular carcinoma.