PIVKA-II was positively correlated to ALT (rs = 0.143, 95% CI 0.027–0.256, p = 0.016), AST (rs = 0.185, 95% CI 0.069–0.297, p = 0.002), total bilirubin (rs = 0.151, 95% CI 0.030–0.268, p = 0.015), HCC nodules number (rs = 0.228, 95% CI 0.056–0.387, p = 0.010) and size of the major HCC nodule (rs = 0.418, 95% CI 0.262–0.552, p < 0.001). Here, GPT is linked to hepatocellular carcinoma.