The increased mRNA levels of the four selected APR (Hp, Serpina3n, C3, Saa1) in skeletal muscle from two other distinct preclinical models of cancer cachexia, namely BaF3 and KP53, suggest that their induction is not specific to the C26 cachexia model, but results more probably from a generalized response to cancer cachexia. This evidence concerns the gene C3 and cancer.