Similarly, Hp seems also to have a protective role because Hp knock-out mice (Hp−/−) have been characterized by muscle atrophy and weakness due to the activation of an atrophy program [13] Moreover, a recent study has shown that Serpina3n overexpression had a profound protective effect on skeletal muscle by attenuating muscular dystrophy in the mdx or Sarcoglycan Delta (Sgcd)−/− backgrounds [17]. The gene discussed is HP; the disease is muscular dystrophy.