Of note, the over-expression of PVT1 was reported in a wide range of cancers, including breast, gastric, non-small cell lung cancers (NSCLC), pancreatic and hepatocellular carcinomas, and acute promyelocytic leukemia (APL), and serves as a predictor of tumor progression and prognosis [161,163,164,165,166,167]. Here, PVT1 is linked to cancer.