MYC and Burkitt lymphoma: Furthermore, PVT1 is often involved in DNA rearrangements (e.g., translocations in Burkitt lymphoma, fusion genes with NBEA and WWOX in multiple myeloma, APIP, ATE1, and PPAPDC1A in the human gastric cell line), which could activate Myc by disrupting the gene structure or protein production [146,155,156,157,158,159,160].