Our data are in accordance with these findings, since rats suffering from HD-induced obesity and HFpEF, showed an impaired antioxidant status (downward trend for the GSH/GSSG ratio with a significant decrease in total antioxidant capacity, catalase activity and uric acid levels), and increased oxidative damage, measured as circulating MDA, and hydroperoxides as well as a pro-inflammatory status. Here, CAT is linked to obesity due to melanocortin 4 receptor deficiency.