IFNA1 and neoplasm: Viral dsRNA in the cytoplasm of infected cells is detected by PRRs such as RIG-I, MDA5, PKR or Toll-like receptor-3 [91,92] and triggers the transcription of type I IFNs from both infected tumour cells and immune cells; dendritic cells (DCs) and monocytes are important in the detection of reovirus and secretion of IFN-α [35,85,93].