In addition, by developing an in vitro VHL-capture-based binding assay combined with a genome-wide screening strategy, we have demonstrated that the zinc fingers and homeoboxes 2 (ZHX2) and the Scm-like with four malignant brain tumor domains 1 (SFMBT1) transcription factors served as novel pVHL substrates in ccRCC [92,93]. This evidence concerns the gene ZHX2 and nonpapillary renal cell carcinoma.