NFKB1 and Parkinson disease: However, since in the present study, NFκB stimulation triggered caspases-2 and -8 expressions in 6OHDA-treated dDCNs, it is tempting to assume that NFκB activation may lead to activation of these caspases in SARS-CoV-2 infection as well, causing apoptotic cell death and consequently promoting the development of PD and COVID-19 (Figure 5).