KRT8 and coronary artery disorder: As expected, the stimulation of CAD PBMCs with keratin 8 did not tend to elevate the PD-1 transcripts, signifying an aberrant peripheral tolerance in CAD patients due to massive inflammatory responses against the self-antigen which could be the cause for impaired PD-1 expression, while keratin 8 increased the PD-1 mRNA on PBMCs obtained from control subjects [132].