This led to a ground-breaking interventional approach for cancer therapy, where many cancer patients who were refractory to conventional chemotherapies benefited from PD-1 blockades and thereby the PD-L1/PD-1 axis blockade finally culminated in the Nobel Prize award in physiology and medicine being awarded in the year 2018 for a revolutionized accomplishment in the field of cancer therapeutics [39,40]. Here, CD274 is linked to cancer.