Though compelling evidence has shed light upon the constructive role of PD-1 and PD-L1 upregulation in atherogenic cells for endorsing possible cardioprotective outcomes, detailed prospective investigations must be unquestionably carried out to investigate whether the agonistic antibodies that stimulate PD-1 and/or PD-L1 and PD-L2 molecules could converge into a rewarding therapeutic approach to treat atherosclerosis. This evidence concerns the gene CD274 and atherosclerosis.