Furthermore, five of these proteins were identified as significantly differentially expressed between PM and PNMs in two NCBI GEO datasets and the gene expression of 6 of these 16 significantly differentially expressed proteins (i.e., EVPL, POSTN, KRT9, MYH9, MYH16 and PEBP1) each had a significant effect on 3-year survival rates in cutaneous melanoma as identified from the TCGA database. The gene discussed is POSTN; the disease is cutaneous melanoma.