CD8A and cancer: In addition, an increase in granzyme B signalling (an important protease in the CD8+ cytotoxic T cells arsenal) was noted; however, IPA also indicated inhibition of signalling of eomesodermin (EOMES) which is also highly expressed in CD8+ T cells but seems to play a complex role in antitumour responses with some evidence for the promotion of adaptive immune responses against cancer but also in promoting CD8+ T cell exhaustion [45,46].