Melittin can also induce caspase-dependent apoptosis in melanoma cells also by displaying a downregulation of phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), mammalian Target of Rapamycin (mTOR) and 5’ adenosine monophosphate-activated protein kinase (MAPK) signaling pathways [21]. This evidence concerns the gene MTOR and melanoma.