Xiao et al. substantiated the pro-tumorigenic effects of sympathetic signaling in PDAC by showing that β2-AR regulates the expression of aldo-keto reductase family 1 member B (AKR1B1) in human pancreatic cancer cells and promotes their proliferation via the ERK1/2 pathway [64]. The gene discussed is AKR1B1; the disease is familial pancreatic carcinoma.