AKT1 and colonic neoplasm: The pro-tumorigenic effects of adrenergic signaling in colorectal cancer is dependent on EGFR- protein kinase B (PKB/Akt)/ERK1/2 signaling [60], while Han et al. unveiled a norepinephrine-CREB1-miR-373 axis that promotes the progression of colon cancer by downregulating tissue inhibitor of metalloproteinases (TIMP2) and adenomatous polyposis coli tumor suppressors [61].