LMNA and familial dilated cardiomyopathy: We show that in transfected cells expressing a DCM-causing LMNA mutation and in skeletal myoblasts from two individuals harboring different L-CMD mutations, PKC-α was found to have increased nuclear localization compared to cells expressing WT LMNA. On the other hand, transfected cells expressing a truncated lamin A/C variant that lacked the PKC-α binding domain presented with PKC-α that was mostly cytoplasmic.