TNFRSF8 and mature T-cell and NK-cell non-Hodgkin lymphoma: Brentuximab Vedotin, an antibody drug conjugate to CD30, has an ORR of 86% in relapsed and refractory anaplastic large cell lymphoma (ALCL) but is not applicable to most other peripheral T cell lymphomas (PTCL) subtypes, which do not express CD30 [4].