SHBG and polycystic ovary syndrome: The specific mechanisms by which bariatric surgery improves the metabolic or reproductive profiles among obese PCOS women remain uncertain, but they are possibly related to the marked reduction in BW associated with an improvement of IR, a reduction in circulating insulin levels, and, consequently, a decline in circulating androgen levels and an increase in sex hormone binding globulin (SHBG) levels [1].