Abu Hashim et al. found that poor reproductive performance of CC-resistant PCOS women after LOD can be predicted if the patients have had a long duration of infertility > 3 years, low basal LH levels < 10 IU/L, marked biochemical hyperandrogenism (testosterone levels ≥ 4.5 nmol/L, free androgen index > 15), and high basal AMH ≥ 7.7 ng/mL [31]. Here, PLOD1 is linked to polycystic ovary syndrome.