INS and polycystic ovary syndrome: Taken together, all these factors result in the activation and augmentation of this vicious cycle (anovulation, hyperandrogenism, the chronic inflammation and imbalance of oxidative and anti-oxidative processes, disturbances of homeostasis in normal follicular development, maturation, and an ovulating or atresia state); therefore, greater androgen production, more insulin formation, and more severe IR occurs in PCOS women.