Thus, miR-155 demonstrate pro-inflammatory activity [13] and regulates destructive processes in rheumatoid arthritis synovial fibroblasts (RASFs) because of the matrix metalloproteinases MMP-1 and MMP-3 expression repression [14], as well as miR-522 that regulate the expression of proinflammatory cytokines and MMPs via targeting SOCS3 [15]. This evidence concerns the gene MMP3 and rheumatoid arthritis.