IGHE and Cerebellar atrophy: The A-T diagnosis is made by association of clinical features and specific laboratory findings, such as cerebellar atrophy on magnetic resonance imaging and lack of voluntary movement coordination, including gait abnormality, elevated serum alpha-fetoprotein (AFP) levels after two years of age, low serum levels of immunoglobulins (IgA, IgG, IgG subclasses and IgE), and lymphopenia [2,6,11].