MAPK8 and early-onset autosomal dominant Alzheimer disease: Some examples of DEGs showing different gene expression in females when compared to males included Mapk8, Uqcrc1, Cdc26, Rnf7 and Sv2b. These DEG regulate 98 pathways including Alzheimer’s disease, ubiquitin mediated proteolysis, and extracellular matrix (ECM) receptor pathways, to name a few.