Fifteen percent of the DEGs showed opposite expression patterns in males and females, with 25 genes down regulated in females and up regulated in males such as Cycs, Npy, Fabp5, Exoc3, Lamp1 that regulate pathways such as apoptosis, tight junction, adipocytokine signaling pathway, stress induction of HSP regulation, phagosome, and also Alzheimer’s disease. The gene discussed is HSP90B2P; the disease is early-onset autosomal dominant Alzheimer disease.