LDLR and hyperlipidemia: In order to better understand the complexity and sex specificity of molecular regulation of the hippocampal brain microvasculature in response to the Western diet (WD), we characterized sex differences in the molecular mechanisms for the genomic effects of a high fat diet and experimental hyperlipidemia on brain microvascular endothelium of wild type and LDL-R-/- deficient mice (LR) by performing a global sex/gender transcriptomic analysis (SGTA) of laser-captured isolated microvessels from hippocampal regions of the brain.