KRAS and colorectal carcinoma: For instance, the combination of tremelimumab and durvalumab is actually under investigation in three different settings: in MSS mCRC after palliative radiotherapy (NCT03007407), as a combination partner for chemotherapy in the first line treatment of KRAS mutant mCRC (NCT03202758), and in advanced unresectable and treatment-refractory CRC in a randomized, open-label trial comparing with best supportive care (NCT02870920).